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PNS originated in 1979-80 as the Philadelphia Clinical Neuropsychology Group and served as the early source of communication and collaboration among a growing group of clinicians practicing neuropsychology in the greater Delaware Valley. It was among the earliest regional neuropsychology organizations in the United States. The journal Neuropsychology was founded by PNS in 1988 and published at Drexel University until APA bought the journal in 1990. PNS has been sponsoring bi-annual symposia since 1982 featuring prominent neuropsychologists.

PNS is composed of individuals interested in brain-behavior relationships. The organization is open to all interested clinicians, researchers, educators, and consumers. PNS promotes professional development by sponsoring annual workshops and serves as a resource in the Delaware Valley for information about neuropsychology.